God has given us life and we grow gradually, develop physically and learn subjects to Earn and live happily. Once a person attains some height and success, believes the result of his efforts not considering the solar system affecting his life every moment and guide as per his actions. Sun is the largest planet in the Galaxy and maintains our life by influencing various aspects including the environment. Sun controls the environment and controls our food, water, and energy. We may earn money but cannot compete for the solar system and totally depends on it.
Circular rhythm is the molecular changes in the body of human or animal during each period of 24 hrs. These changes are governed by SUN, now proved scientifically by Drs. Rosbash, Young and Hall of USA. Proper sleep hygiene is important to run the 24 system of the body called a BODY CLOCK a kind of BLACK BOX controlling body rhythm minute to minute. All these Researchers worked together in 1989 at Brandeis Institute (Waltham – MASSACHUSETTS) and isolated period gene in fruit flies. The protein encoded by this CLOCK GENE accumulates during the night and degraded during day time. It established the key mechanism for this biological clock. Our well being is affected where the temporary mismatch occurs between the External environment and the internal BIOLOGICAL CLOCK, causing draining of body strength and various changes leading to stress state. The example is Jet lag, travel across different time zone and very different experience of total exhaustion.
Chronic misalignment between our life style and body rhythm dictated our inner time keeper producing biological changes at cellular level affecting intra cellular and intra nucleus function. Period GENE encoded with protein, along with TIMELESS GENE enters the cell nucleus and control the frequency of the cycle also.
Sunlight synchronises the CLOCK GENE and control molecular function and metabolic functions. As per SIR PAUL NURSE (Noble Prize Winner in 2001 – on Cell Cycle and Gene encoded protein influencing its function), said that beside many metabolic disorders, even treatment of disease can be influenced by Circadian rhythm. Many Scientist reported the influence of time of treatment and surgery affecting body. Such rhythm correlation is still to be proved but clinical experiences of most of the Doctors did say recovery and wellbeing of patients differ person to person on many known and unknown factors.
More and more health issues are due to genetic defects in the CIRCADIAN CLOCK, or self-imposed problem by WORK or JET LAG. This internal timer is constantly struggling to reset to the environment and hard pressed if put to pressure frequently in days or week leading to metabolic disorders, diabetes, hypertension, fluid retention /depletion, electrolyte imbalance etc.
Glucose metabolism is affected most in the acute stage with inadequate pancreatic Insulin Secretion. Other hormones in the body also get affected with infrequent and long circadian disruption like Thyroid, Adrenals and others. It Intra nuclear changes are also seen in Neurons, Cardiac Cells and GI secreting cells. Obesity is proved with repeated cyclic changes in the internal clock. High fat feeding provided at the incorrect circadian time leads to greater weight gain in mice then iso caloric feeding at the normal circadian time.
Supra chiasmatic nucleus in the mid brain has its own clock regulating peripheral cell clock, responding during circadian de entrainment period affecting circulating hormones including glucocorticoids. This phase of de entrainment with hormones – specifically glucocorticoids affect body CELL CLOCK and result in cellular metabolic changes affecting different organs like Liver, Kidney and Heart.
Cancer is a metabolic disorder with protein/amino acid alienation with trace elements. In long term effect of circadian rhythm, causing repeated circadian re-entrainment and entrainment may change CELL CLOCK to an abnormal phase of metabolic changes to uninhabited cell proliferation and cancer growth.
Circadian rhythm affect every cell and the body with a change of time, controlled by cosmic sun rays. As time passes much more to learn and act.
